# What is Reye's syndrome and what is its relationship with aspirin use during childhood viral infections? Canonical page: https://clinicsjo.com/en/faq/ma-hi-mutalazimat-ray-wa-alaqatuha-bi-istikhdam-al-asbirin-fi-adwa-al-atfal-al-firusiya Language: en Category: pediatrics Publisher: ClinicsJo Published: 2026-09-13T08:09:52.952Z Content updated: 2026-09-13T08:09:52.952Z Translation (ar): https://clinicsjo.com/ar/faq/ma-hi-mutalazimat-ray-wa-alaqatuha-bi-istikhdam-al-asbirin-fi-adwa-al-atfal-al-firusiya Reye's syndrome is a rare but extremely serious condition that primarily affects the brain and liver. This syndrome causes sudden swelling in the brain, in addition to deterioration of liver function, and its symptoms usually appear during the recovery phase from a viral infection, such as the flu, chickenpox, or the common cold [\[1\]](). Reye's syndrome is classified as a biphasic disease, usually beginning shortly after a child has had a viral infection, and signs of the syndrome may appear five to seven days after the onset of the initial illness [\[2\]](). Although its exact causes are not yet fully understood, there is a well-documented relationship between the use of aspirin (salicylates) to treat symptoms of viral infections in children and adolescents and the onset of this condition [\[3\]](). ## Symptoms of Reye's Syndrome and Warning Signs The symptoms of Reye's syndrome progress very rapidly, requiring urgent medical response. If parents notice sudden behavioral changes or neurological symptoms after a child has had a viral illness, immediate medical attention must be sought [\[3\]](). The most common symptoms include: - Persistent vomiting and nausea [\[2\]]() - Unusual drowsiness, extreme lethargy, or loss of energy [\[2\]]() - Sudden changes in personality or behavior, such as irritability or aggression [\[3\]]() - Confusion, disorientation, or delirium [\[2\]]() - Seizures in advanced cases [\[3\]]() - Loss of consciousness or slipping into a coma [\[2\]]() It should be noted that Reye's syndrome can lead to a rapid decline in bodily functions, including blood clotting disorders, which makes those affected more susceptible to bleeding if they sustain any injury [\[2\]](). ## Why Should Aspirin Be Avoided for Children? Medical recommendations emphasize the necessity of avoiding aspirin entirely for children and adolescents suffering from viral symptoms. Research has shown a strong link between taking this medication during a viral infection and the development of Reye's syndrome. Aspirin is a type of salicylate, a substance also found in many over-the-counter medications, so it is essential to check medication labels carefully before giving them to children [\[2\]](). There is a group of children who may be more susceptible to the risk due to rare metabolic conditions, such as medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. In these cases, the body is unable to properly break down fats, and aspirin becomes a stronger trigger for the onset of the syndrome's symptoms [\[2\]](). ## Alternatives and Medical Management Due to the risks associated with aspirin, it is recommended to use safer alternatives such as acetaminophen or ibuprofen to relieve fever and pain in children with viral infections. However, you should always consult a doctor to determine the appropriate dosage based on the child's age and weight [\[2\]](). If Reye's syndrome is suspected, there is no cure in itself; however, medical treatment in an intensive care unit focuses on maintaining vital functions, reducing brain swelling, and preventing the worsening of liver damage. Early diagnosis and medical intervention are crucial for improving the chances of survival and minimizing permanent neurological damage [\[3\]](). For more information on this topic, you can view [Reye's Syndrome and Aspirin Use in Childhood Viral Infections (Arabic)]() to understand how to protect your children and make safe medical decisions. ## Medical references - [Ammonia Levels]() - [Reye's Syndrome]() - [Reye Syndrome]() General health education; not a substitute for individualized clinical assessment. Citation URL: https://clinicsjo.com/en/faq/ma-hi-mutalazimat-ray-wa-alaqatuha-bi-istikhdam-al-asbirin-fi-adwa-al-atfal-al-firusiya#answer