# What are the most common side effects of chemotherapy? Canonical page: https://clinicsjo.com/en/faq/ma-hia-alathar-aljanibia-alacthar-shiueaan-lililaj-alkimiaii Language: en Category: oncology Publisher: ClinicsJo Published: 2026-09-13T08:09:50.988Z Content updated: 2026-09-13T08:09:50.988Z Translation (ar): https://clinicsjo.com/ar/faq/ma-hia-alathar-aljanibia-alacthar-shiueaan-lililaj-alkimiaii Chemotherapy uses powerful drugs to destroy cancer cells, but it may also affect healthy cells in the body, leading to side effects. These effects vary in intensity and type from one person to another and depend on the type of chemotherapy, the dosage, and how the body responds to it [\[1\]](). The most common side effects of chemotherapy include the following: ## Nausea and Vomiting Nausea and vomiting are common side effects that chemotherapy drugs can cause. Their severity can range from mild to severe, and they may appear immediately after treatment or after several hours. Fortunately, many anti-nausea medications are available that can help manage these symptoms [\[2\]](). ## Fatigue and Exhaustion Feeling extremely tired and exhausted is a prevalent side effect of chemotherapy. This fatigue may be different from ordinary tiredness and does not go away with rest. It is very important to listen to your body and get enough rest. Light walking and moderate physical activity, after consulting with a doctor, can help improve energy levels [\[1\]](). ## Hair Loss Hair loss is a well-known side effect of chemotherapy, as the drugs target fast-growing cells, including hair follicles. Hair loss usually begins a few weeks after treatment starts and may include hair on the scalp and body. In most cases, hair grows back after chemotherapy ends [\[1\]](). ## Mouth Sores and Mucositis Chemotherapy can lead to dry mouth or painful sores in the mouth and throat, making eating and drinking difficult. Good oral care is essential to prevent and manage these problems. It is recommended to clean teeth and gums 2 to 3 times daily with a soft toothbrush and use a special mouthwash recommended by a doctor, such as a solution of water, salt, and baking soda [\[2\]](). ## General Tips for Managing Side Effects It is essential to maintain constant communication with your healthcare team to discuss any side effects you encounter. The doctor or nurse can provide guidance on how to manage these effects and may prescribe medications to alleviate them. Remember that most side effects gradually disappear after chemotherapy ends, as healthy cells recover [\[1\]](). For more information on managing chemotherapy side effects, you can visit [Managing Chemotherapy Side Effects: A Comprehensive Guide for Patients (Arabic)](). ## When Should You Contact the Doctor? You should contact your healthcare team immediately if you experience any of the following symptoms, as they may indicate a serious problem requiring urgent medical attention: - Signs of infection such as fever, chills, or sweating [\[2\]](). - Diarrhea that does not stop or contains blood [\[2\]](). - Severe nausea and vomiting that prevent you from eating or drinking [\[2\]](). - Severe weakness or inability to eat or drink [\[2\]](). - Redness, swelling, or discharge from the intravenous line insertion site [\[2\]](). - New skin rash or blisters [\[2\]](). - Jaundice (yellowing of the skin or whites of the eyes) [\[2\]](). - Abdominal pain [\[2\]](). - A headache that is very severe or does not go away [\[2\]](). - Worsening cough or difficulty breathing while resting or performing simple tasks [\[2\]](). - Burning sensation during urination [\[2\]](). ## Medical references - [Cancer Chemotherapy]() - [After chemotherapy - discharge]() - [Chemotherapy and You: Support for People With Cancer]() General health education; not a substitute for individualized clinical assessment. Citation URL: https://clinicsjo.com/en/faq/ma-hia-alathar-aljanibia-alacthar-shiueaan-lililaj-alkimiaii#answer