# What are the treatment options for von Hippel-Lindau (VHL) disease? Canonical page: https://clinicsjo.com/en/faq/ma-hiya-khiarat-ilaj-marad-von-hippel-lindau-vhl Language: en Category: oncology Publisher: ClinicsJo Published: 2026-09-13T17:52:53.800Z Content updated: 2026-09-13T17:52:53.800Z Translation (ar): https://clinicsjo.com/ar/faq/ma-hiya-khiarat-ilaj-marad-von-hippel-lindau-vhl Treatment options for von Hippel-Lindau (VHL) disease vary significantly between individuals, as they depend on the number, location, and size of the tumors or cysts in the body. Treatment involves continuous monitoring and may include surgery, radiation therapy, or medications, with the goal of managing symptoms and preventing serious complications. Treatment focuses on early intervention when tumors or cysts are detected. ## Continuous Monitoring and Early Intervention Continuous medical evaluation is an essential part of managing von Hippel-Lindau disease. Regular check-ups allow physicians to monitor tumors or cysts and treat them early when necessary. This monitoring can help determine when treatment is required and when a wait-and-watch approach is safe, especially with hemangioblastomas that may not change for long periods [\[1\]](). ## Surgical and Radiation Treatment Options Surgery is a common treatment option for removing tumors or cysts that cause symptoms or pose a life-threatening risk. For example, hemangioblastomas can enlarge and press on the brain or spinal cord, necessitating surgical removal to restore normal functions such as vision or hearing [\[1\]](). Safer surgical methods have also been developed to remove tumors in difficult-to-reach areas, such as the brainstem [\[1\]](). Radiation therapy may also be an option in some cases, depending on the type and location of the tumor. ## Pharmacological Treatments Medications have emerged as an important part of the treatment plan for von Hippel-Lindau disease. For instance, belzutifan (Welireg) is a new available drug that can slow tumor growth and prevent the growth of new tumors [\[1\]](). However, some tumors may continue to grow even with this medication, and the patient may eventually require surgery [\[1\]](). Other medications, such as vorinostat (Zolinza), are being tested to see if they can slow tumor growth in some people with VHL syndrome [\[1\]](). ## Importance of Multidisciplinary Care Because von Hippel-Lindau disease can affect multiple parts of the body, care from a multidisciplinary medical team is crucial. This approach ensures that all symptoms are addressed and care is coordinated effectively. The team may include neurologists, oncologists, ophthalmologists, and other specialists as needed [\[2\]](). For more information on this disease, you can visit the page: [Von Hippel-Lindau Disease: Understanding the Genetic Syndrome and Treatment Options (Arabic)](). ## Participation in Clinical Trials Clinical trials can provide opportunities to access new and future treatment options. These studies contribute to a better understanding of the disease and the development of safer and more effective methods for detecting, treating, or preventing it. People with VHL syndrome are encouraged to consider participating in clinical trials to help advance research [\[1\]](). ## Medical references - [Von Hippel-Lindau (VHL) Syndrome]() - [Von Hippel-Lindau syndrome]() General health education; not a substitute for individualized clinical assessment. Citation URL: https://clinicsjo.com/en/faq/ma-hiya-khiarat-ilaj-marad-von-hippel-lindau-vhl#answer