What is tumour next-generation sequencing, and does every cancer patient need it?
Next-generation sequencing examines multiple DNA changes and may guide treatment or clinical-trial options in selected situations. It is most useful when results could change care. Tumour profiling is different from testing for inherited cancer susceptibility.
Details
Match the sample to the clinical question
Testing may use tumour tissue or tumour-derived DNA in blood. Liquid biopsy is not a complete replacement for tissue in every situation. A negative result may reflect little tumour DNA or test limitations and does not rule out cancer.
Interpret results carefully
Testing may find a treatment target, no useful target, or variants of uncertain significance. An uncertain result alone should not determine treatment or preventive surgery. A possible inherited finding may require separate confirmatory testing and genetic counselling.
Discuss the practical value
Ask whether a smaller targeted test would suffice, whether relevant medicines or trials are accessible, and about turnaround time and cost. Timing and repeat testing depend on the cancer and its course. A larger panel is not automatically better for everyone.
Related reading: Is cancer hereditary, and when should a family consider genetic counselling?.